Preferred Label : Lipid Nanoparticle Encapsulated MYC-targeting mRNA-based Agent OTX-2002;
NCIt synonyms : LNP Encapsulated MYC-targeting mRNA-based Agent OTX-2002;
NCIt definition : A lipid nanoparticle (LNP)-based formulation consisting of a biscistronic mRNA that
encodes two independent epigenomic controllers targeting the proto-oncogene MYC (c-Myc),
with potential antineoplastic activity. Upon administration of LNP encapsulated MYC-targeting
mRNA-based agent OTX-2002, the lipid formulation promotes the uptake by tumor cells.
The biscistronic mRNA is then translated by the cellular protein translation machinery
to produce two independent epigenomic controllers consisting of a DNA binding domain
and an epigenetic effector protein. The two epigenomic controllers bind to regulatory
regions on the MYC insulated genomic domain (IGD), a DNA loop bound by CTCF (CCCTC-binding
factor). This downregulates MYC expression pre-transcriptionally, which may inhibit
proliferation in susceptible tumor cells. MYC, a proto-oncogene overexpressed in a
variety of cancers, plays a role in the regulation of transcription and cell proliferation.;
Molecule name : OTX 2002; OTX-2002;
NCI Metathesaurus CUI : CL1798749;
Origin ID : C190153;
UMLS CUI : C5761788;
Semantic type(s)
- concept_is_in_subset
- has_target
