Activin Receptor Type-1

Preferred Label : Activin Receptor Type-1;

NCIt synonyms : ACVR1; Activin A Receptor, Type II-Like Kinase 2; ACTR-I; SKR1; Activin A Receptor, Type I; TSR-I; Serine/Threonine-Protein Kinase Receptor R1; Activin Receptor Type I; Activin Receptor-Like Kinase 2; EC 2.7.11.30; ALK-2; TGF-B Superfamily Receptor Type I; Activin A Receptor Type-I;

NCIt definition : Activin receptor type-1 (509 aa, 57 kDa) is encoded by the human ACVR1 gene. This protein is involved in embryonic development, protein phosphorylation, and signal transduction.;

NCIt note : Type I receptors are essential for transmembrane signaling and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors.;

Details

Origin ID

C26612;

UMLS CUI

C1447968;

OMIM relation
- Activin a receptor, type I [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- ACVR1 protein, human [MeSH Supplementary Concept]
- ACVR1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ACVR1 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Serine/Threonine Kinase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- TGF-beta Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Itacnosertib [NCIt concept]
- Momelotinib [NCIt concept]
- Momelotinib Dihydrochloride [NCIt concept]
- Momelotinib Dihydrochloride Monohydrate [NCIt concept]
- Zilurgisertib [NCIt concept]

Keyword's position in hierarchy(ies) :

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