Preferred Label : LEFTY2 wt Allele;
NCIt synonyms : LEFTYA; EBAF; TGF-Beta 4 Gene; MGC46222; TGFB4; Left-Right Determination Factor 2 wt Allele; LEFTA; LEFTY2, Mouse, Homolog of Gene; Left-Right Determination, Factor A Gene; EBAF wt Allele; Transforming Growth Factor, Beta-4 (Endometrial Bleeding-Associated Factor; LEFTY
A) Gene; LEFTY2 Transforming Growth Factor, Beta-4 Gene; Endometrial Bleeding Associated Factor (Left-Right Determination, Factor A; Transforming
Growth Factor Beta Superfamily) Gene; PSEC0024;
NCIt definition : Human LEFTY2 wild-type allele is located in the vicinity of 1q42.1 and is approximately
5 kb in length. This allele, which encodes left-right determination factor 2 protein,
plays a role in the left-right asymmetry determination of organ systems during development
and is also involved in endometrial bleeding regulation. Mutations in this gene produce
variant alleles that are associated with left-right axis malformations, particularly
in the heart and lungs. Further, certain types of infertility have been associated
with aberrant allelic expression in the endometrium.;
GenBank Accession Number : NM_003240;
Origin ID : C51538;
UMLS CUI : C1705439;
OMIM relation
- Semantic type(s)
- gene_associated_with_disease
- gene_found_in_organism
- gene_has_physical_location
- gene_in_chromosomal_location
- gene_is_element_in_pathway
- gene_plays_role_in_process
