" /> LEFTY1 wt Allele - CISMeF





Preferred Label : LEFTY1 wt Allele;

NCIt synonyms : LEFTB Gene; LEFTYB; Left-Right Determination Factor 1 wt Allele; LEFTB; Left-Right Determination, Factor B Gene; UNQ278/PRO317; LEFTB wt Allele; LEFTY1, Mouse, Homolog of Gene;

NCIt definition : Human LEFTY1 wild-type allele is located in the vicinity of 1q42.1 and is approximately 3 kb in length. This allele, which encodes left-right determination factor B protein, plays a role in left-right asymmetry determination of organ systems during development.;

NCIt note : Closely linked to a related pseudogene, the 2.9-kb human LEFTB Gene (TGF-Beta Family) at 1q42.1 is separated by approximately 50-kb from the related LEFTYA gene. Both genes comprise four exons spliced at identical positions and encode strongly similar secreted proteins. Containing a TGF-beta family domain, 366-amino acid 41-kD Left-Right Determination Factor B (preproprotein) undergoes cell-specific alternative processing into three different products. Processing may occur at R-X-X-R sites. LEFTB appears required for left-right determination during early presomite development in mammals. It may serve as a feedback inhibitor to restrict the range of nodal signaling during establishment of the axis.;

GenBank Accession Number : NM_020997;

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07/05/2025


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