Activin Receptor Type-1C

Preferred Label : Activin Receptor Type-1C;

NCIt synonyms : EC 2.7.11.30; Activin Receptor-Like Kinase 7; ACTR-IC; Activin Receptor Type IC; ALK-7;

NCIt definition : Activin receptor type-1C (493 aa, 55 kDa) is encoded by the human ACVR1C gene. This protein plays a role in both cytokine signaling and serine/threonine phosphorylation.;

NCIt note : Activin receptor type-1C forms a receptor complex on ligand binding which consists of 2 type II and 2 type I transmembrane serine/threonine receptor kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate. Phosphorylated type I receptors then bind and phosphorylate SMAD2 and SMAD3. (UniProt);

Details

Origin ID

C96021;

UMLS CUI

C1429973;

OMIM relation
- Activin a receptor, type ic [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- ACVR1C protein, human [MeSH Supplementary Concept]
- ACVR1C protein, human [MeSH concept]
gene_encodes_gene_product
- ACVR1C Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Serine/Threonine Kinase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- TGF-beta Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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