NODAL wt Allele

Preferred Label : NODAL wt Allele;

NCIt synonyms : MGC138230; Nodal, Mouse, Homolog Gene; Nodal, Mouse, Homolog of Gene; Nodal Growth Differentiation Factor wt Allele; Nodal Homolog (Mouse) Gene; HTX5;

NCIt definition : Human NODAL wild-type allele is located in the vicinity of 10q22.1 and is approximately 10 kb in length. This allele, which encodes nodal homolog protein, plays a role in the modulation of embryonic mesoderm and axis formation. Mutation of the gene is associated with visceral heterotaxy autosomal type 5.;

NCIt note : The NODAL gene and the ACVR1C gene may suppress ovarian cancer cell proliferation. (J. Clin. Endocrinol. Metab. 2004; 89: 5523-5534.);

GenBank Accession Number : BC033585;

Details

Origin ID

C96044;

UMLS CUI

C3272514;

Automatic exact mappings (from CISMeF team)
- Heterotaxy, visceral, 5, autosomal [OMIM Phenotype]
OMIM relation
- Nodal growth differentiation factor [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_is_element_in_pathway
- TGF-beta Signaling Pathway KEGG [NCIt concept]
gene_plays_role_in_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Generalized Growth [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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