Activin Receptor Type-2A

Preferred Label : Activin Receptor Type-2A;

NCIt synonyms : ACTR-II; ACVR2; ACTRIIA; Activin A Type II Receptor; EC 2.7.11.30; ACTR-IIA; Activin Receptor Type IIA; Activin-A Type-II Receptor;

NCIt definition : Activin receptor type-2A (513 aa, 58 kDa) is encoded by the human ACVR2A gene. This protein is involved in signal transduction and embryonic development.;

NCIt note : Type I receptors are essential for transmembrane signaling and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors.;

Details

Origin ID

C21272;

UMLS CUI

C2003673;

Currated CISMeF NLP mapping
- activin receptor type II-A [MeSH concept]
- activin receptor type II-A [MeSH Supplementary Concept]
OMIM relation
- Activin a receptor, type iia [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ACVR2A protein, human [MeSH concept]
gene_encodes_gene_product
- ACVR2A Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Serine/Threonine Kinase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- TGF-beta Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Sotatercept [NCIt concept]

Keyword's position in hierarchy(ies) :

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