Preferred Label : Anti-PD-L1/TGFbetaRII Fusion Protein BJ-005;
NCIt synonyms : Anti-PD-L1/TGF-beta Receptor II Bispecific Fusion Protein BJ-005; Bispecific Fusion Protein BJ-005;
NCIt definition : A recombinant bifunctional fusion protein composed of a humanized immunoglobulin (Ig)
G1 anti-programmed death ligand 1 (PD-L1) monoclonal antibody fused to the extracellular
domain (ECD) of the human transforming growth factor beta (TGFbeta) receptor type
II (TGFbetaRII), with potential antineoplastic and immune checkpoint modulating activities.
Upon administration of anti-PD-L1/TGFbetaRII fusion protein BJ-005, the TGFbetaRII
moiety targets, binds to and neutralizes TGFbeta while the antibody moiety simultaneously
targets, binds to, and inhibits the activity of PD-L1 on the tumor cell. This prevents
both TGFbeta- and PD-L1-mediated immuno-suppressive pathways signaling, and increases
natural killer (NK) cell and cytotoxic T-lymphocyte (CTL) activities. This restores
and enhances anti-tumor responses and inhibits tumor cell proliferation in susceptible
tumor cells. TGFbeta and PD-L1 are both upregulated in certain types of cancers and
and play key roles in tumor immune suppression; their overexpression is associated
with increased evasion of immune surveillance and contributes to poor prognosis.;
Molecule name : BJ 005; BJ-005;
NCI Metathesaurus CUI : CL1773736;
Origin ID : C185426;
UMLS CUI : C5666995;
Semantic type(s)
- concept_is_in_subset
- has_target
