Preferred Label : Bintrafusp Alfa;
NCIt synonyms : M7824; Anti-PDL1/TGFb Trap MSB0011359C;
NCIt related terms : Anti-PD-L1/TGFbetaRII Fusion Protein M7824;
NCIt definition : A bifunctional fusion protein composed of an anti-programmed death ligand 1 (PD-L1)
human monoclonal antibody, bound to the soluble extracellular domain of human transforming
growth factor beta (TGFbeta) receptor type II (TGFbetaRII), with potential antineoplastic
and immune checkpoint modulating activities. Upon administration, bintrafusp alfa
binds to and neutralizes activated TGFbeta and binds to PD-L1. This prevents TGFbeta-
and PD-L1-mediated signaling, and increases natural killer (NK) cell and cytotoxic
T-lymphocyte (CTL) activities. This inhibits tumor cell proliferation in susceptible
tumor cells. TGFbeta and PD-L1 are both upregulated in certain types of cancers; their
overexpression is associated with increased evasion of immune surveillance and contributes
to poor prognosis.;
UNII : NW9K8C1JN3;
CAS number : 1918149-01-5;
Molecule name : MSB0011359C;
NCI Metathesaurus CUI : CL502609;
Origin ID : C124229;
UMLS CUI : C5139699;
Semantic type(s)
- concept_is_in_subset
- has_target
