Preferred Label : TGF-beta2 Antisense Oligonucleotide TASO-001;
NCIt synonyms : TGF-beta2-targeting Antisense Oligonucleotide TASO-001; TGF-beta2 ASO TASO-001;
NCIt definition : A transforming growth factor (TGF)-beta2 specific antisense oligodeoxynucleotide (ASO),
with potential antineoplastic activity. Upon administration, TGF-beta2 ASO TASO-001
binds to TGF-beta2 mRNA causing inhibition of protein translation. This decreases
TGF-beta2 levels, which may result in the inhibition of tumor cell growth and migration,
and tumor angiogenesis. TGF-beta2, a cytokine overexpressed in various malignancies,
may play an important role in promoting the growth, progression, and migration of
tumor cells.;
Molecule name : TASO 001; TASO-001;
NCI Metathesaurus CUI : CL1663083;
Origin ID : C180506;
UMLS CUI : C5556425;
Semantic type(s)
- concept_is_in_subset
- has_target
