Preferred Label : Anti-PD-L1/TGFbetaRII Fusion Protein 6MW3511;
NCIt synonyms : Anti-PD-L1 Nanobody/TGFbetaRII Mutant Fusion Protein 6MW3511; Anti-PD-L1/TGFbetaRII Bifunctional Fusion Protein 6MW3511;
NCIt definition : A bifunctional fusion protein composed of a humanized anti-programmed death ligand
1 (PD-L1) nanobody fused to a mutant form of the human transforming growth factor
beta (TGFbeta) receptor type II (TGFbetaRII), with potential antineoplastic and immune
checkpoint modulating activities. Upon administration of anti-PD-L1/TGFbetaRII fusion
protein 6MW3511, the TGFbetaRII moiety targets, binds to and neutralizes TGFbeta while
the anti-PD-L1 nanobody moiety simultaneously targets, binds to, and inhibits the
activity of PD-L1 on the tumor cell. This prevents both TGFbeta- and PD-L1-mediated
immuno-suppressive pathways signaling, and increases natural killer (NK) cell and
cytotoxic T-lymphocyte (CTL) activities. This restores and enhances anti-tumor immune
responses and inhibits tumor cell proliferation in susceptible tumor cells. TGFbeta
and PD-L1 are both upregulated in certain types of cancers and play key roles in tumor
immune suppression; their overexpression is associated with increased evasion of immune
surveillance and contributes to poor prognosis. The TGFbetaRII moiety is modified
to enhance the stability of the agent.;
Molecule name : 6MW3511;
NCI Metathesaurus CUI : CL1905575;
Origin ID : C192171;
UMLS CUI : C5784957;
Semantic type(s)
- concept_is_in_subset
- has_target
