NCIt definition : A transforming growth factor (TGF)-beta2 specific phosphorothioate antisense oligodeoxynucleotide
with the sequence 5'-CGGCATGTCTATTTTGTA-3', with potential antineoplastic activity.
Trebedersen binds to TGF-beta2 mRNA causing inhibition of protein translation, thereby
decreasing TGF-beta2 protein levels; decreasing intratumoral TGF-beta2 levels may
result in the inhibition of tumor cell growth and migration, and tumor angiogenesis.
TGF-beta2, a cytokine often over-expressed in various malignancies, may play an important
role in promoting the growth, progression, and migration of tumor cells.;
UNII : 98OYR854NY;
CAS number : 925681-61-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 925681-61-4
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