NCIt definition : A transforming growth factor (TGF)-beta2 specific phosphorothioate antisense oligodeoxynucleotide
with the sequence 5'-CGGCATGTCTATTTTGTA-3', with potential antineoplastic activity.
Trebedersen binds to TGF-beta2 mRNA causing inhibition of protein translation, thereby
decreasing TGF-beta2 protein levels; decreasing intratumoral TGF-beta2 levels may
result in the inhibition of tumor cell growth and migration, and tumor angiogenesis.
TGF-beta2, a cytokine often over-expressed in various malignancies, may play an important
role in promoting the growth, progression, and migration of tumor cells.;