Preferred Label : PD-L1 Inhibitor INCB086550;
NCIt synonyms : PD-1 Ligand 1 Inhibitor INCB086550;
NCIt related terms : INCB-086550;
NCIt definition : An orally available, small molecule inhibitor of the immunosuppressive ligand, programmed
cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274) with potential
immune checkpoint inhibitory and antineoplastic activities. Upon administration, PD-L1
inhibitor INCB086550 specifically targets PD-L1 expressed on tumor cells preventing
the binding and subsequent activation of its receptor, programmed cell death 1 (PD-1;
PDCD1; CD279; programmed death-1). This reverses T-cell inactivation caused by PD-L1/PD-1
signaling, increases T-cell expansion and enhances the cytotoxic T-lymphocyte (CTL)-mediated
anti-tumor immune response against PD-L1-expressing tumor cells. PD-L1, a transmembrane
protein expressed on activated T-cells, is overexpressed in some cancer types and
plays a significant role in immune evasion by tumor cells.;
UNII : T8B91S15VF;
CAS number : 2230911-59-6;
Molecule name : INCB-86550; INCB-086550; INCB 86550; INCB 086550;
NCI Metathesaurus CUI : CL937968;
Origin ID : C158532;
UMLS CUI : C4764270;
Semantic type(s)
- concept_is_in_subset
- has_target
