Preferred Label : Anti-PD-L1 Antibody-drug Conjugate SGN-PDL1V;
NCIt synonyms : Anti-PD-L1 Vedotin ADC SGN-PDL1V; Anti-PD-L1 ADC SGN-PDL1V;
NCIt definition : An antibody-drug conjugate (ADC) composed of an antibody directed against the immunosuppressive
ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274),
conjugated to the cytotoxic agent monomethyl auristatin E (MMAE) via a protease-cleavable
peptide linker, with potential antineoplastic activity. Upon administration of the
anti-PD-L1 ADC SGN-PDL1V, the anti-PD-L1 antibody specifically targets and binds to
PD-L1 expressed on tumor cells. Following internalization, enzymatic cleavage and
release of MMAE, MMAE targets and binds to tubulin, and inhibits microtubule polymerization.
This results in G2/M phase cell cycle arrest and apoptosis in PD-L1-expressing tumor
cells. PD-L1, a transmembrane protein, is expressed on the surface of certain immune
cells and on many cancer cell types. PD-L1 binding to PD-1, a negative regulator of
the immune system on activated T-cells, limits the expansion and survival of CD8-positive
T-cells, suppresses the immune system and results in immune evasion.;
Molecule name : SGN PDL1V; SGN-PDL1V;
NCI Metathesaurus CUI : CL1778586;
Origin ID : C186368;
UMLS CUI : C5667052;
Semantic type(s)
- concept_is_in_subset
- has_target
