Preferred Label : Allogeneic PD-L1 Tumor-targeted High-affinity Natural Killer Cells;
NCIt synonyms : Allogeneic PD-L1 t-haNK; Allogeneic PD-L1-t-haNK; Allogeneic PD-L1-targeting High-affinity NKs;
NCIt definition : A preparation of natural killer (NK) cells that are derived from NK-92 cells, a human
cytotoxic cell line composed of allogeneic NK cells derived from a 50-year old male
patient with rapidly progressive non-Hodgkin's lymphoma (NHL), that are genetically
engineered to express the high-affinity CD16/FcgammaRIIIa (158V) allele, endoplasmic
reticulum (ER)-retained interleukin (IL)-2 and a chimeric antigen receptor (CAR) specific
for programmed death-ligand 1 (PD-L1), with potential immunomodulating, cytolytic
and antineoplastic activities. Upon infusion of the PD-L1 tumor-targeted high-affinity
(ha) NK cells, the NK cells recognize and bind to tumor cells, preferentially to PD-L1-expressing
tumor cells and human peripheral myeloid-derived suppressor cells (MDSCs). This leads
to the secretion and release of perforins, granzymes, cytokines and chemokines, and
results in cancer cell lysis and apoptosis. In addition, the incorporation of the
high-affinity CD16 allele allows the NK cells to lyse tumor cells via antibody-dependent
cell-mediated cytotoxicity (ADCC) mediated by tumor-antigen-specific immunoglobulin
G1 (IgG1) antibodies through binding of CD16 with the Fc region of human IgG1 antibodies.
IL-2 replenishes the granular stock of NK cells, leading to enhanced perforin- and
granzyme-mediated lysis of tumor cells.;
NCI Metathesaurus CUI : CL1407926;
Origin ID : C174011;
UMLS CUI : C5420525;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
