Preferred Label : Anti-PD-L1/IL-15 Fusion Protein SIM0237;
NCIt synonyms : Anti-PD-L1/IL-15/IL-15Ra Sushi Domain Fusion Protein SIM0237;
NCIt definition : A fusion protein composed of a monoclonal antibody directed against the immunosuppressive
ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274),
fused with potency reduced interleukin (IL)-15/IL-15 receptor alpha (IL-15Ra) sushi
domain complex, with potential immunostimulatory and antineoplastic activities. Upon
administration of the anti-PD-L1/IL-15 fusion protein SIM0237, the anti-PD-L1 antibody
moiety specifically targets and binds to PD-L1 expressing cells in the tumor microenvironment
(TME). In turn, the IL-15/IL-15Ra complex stimulates the proliferation of natural
killer (NK) cells, cytotoxic T-lymphocytes (CTLs) and memory T-cells locally in the
TME, which induces an anti-tumor immune response. This may increase tumor cell killing
and decrease tumor cell proliferation. PD-L1, a transmembrane protein, is expressed
on the surface of antigen presenting cells (APCs) and on many cancer cell types. PD-L1
binding to PD-1, a negative regulator of the immune system on activated T-cells, limits
the expansion and survival of CD8-positive T-cells, suppresses the immune system and
results in immune evasion. IL-15 regulates CD8 T and NK cell development, activation
and proliferation. IL-15Ra complexed with IL-15 increases the half-life of IL-15.
The attenuated IL-15 prevents the overstimulation of CD8 T and NK cells.;
Molecule name : SIM 0237; SIM-0237;
NCI Metathesaurus CUI : CL1907096;
Origin ID : C200275;
UMLS CUI : C5854506;
Semantic type(s)
- concept_is_in_subset
- has_target
