B7-H1 Antigen - CISMeF

Preferred Label : B7-H1 Antigen;

MeSH definition : An inhibitory B7 antigen that has specificity for the T-CELL receptor PROGRAMMED CELL DEATH 1 PROTEIN. CD274 antigen provides negative signals that control and inhibit T-cell responses and is found at higher than normal levels on tumor cells, suggesting its potential role in TUMOR IMMUNE EVASION.; An inhibitory B7 antigen that contains V-type and C2 type immunoglobulin domains. It has specificity for the T-CELL receptor PROGRAMMED CELL DEATH 1 PROTEIN and provides negative signals that control and inhibit T-cell responses. It is found at higher than normal levels on tumor cells, suggesting its potential role in TUMOR IMMUNE EVASION.;

MeSH synonym : CD274 antigens; B7-H1 immune costimulatory protein; B7 H1 immune costimulatory protein; programmed cell death 1 ligand 1 protein; CD274 antigen; antigen, CD274; PD-L1 costimulatory protein; costimulatory protein, PD-L1; PD L1 costimulatory protein; programmed cell death 1 ligand 1; antigen, B7-H1; B7 H1 antigen; B7H1 immune costimulatory protein; Antigens, CD274; Programmed Death Ligand 1; PD-L1 Protein; PD L1 Protein;

Is substance : O;

Details

Origin ID

D060890;

UMLS CUI

C3203086;

ATC code(s)
- PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitors [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- CD274 Gene [NCIt concept]
- CD274 wt Allele [NCIt concept]
- Cd274 molecule [OMIM gene]
- Programmed Cell Death 1 Ligand 1 [NCIt concept]
- Programmed Death Ligand 1 Measurement [NCIt concept]
Indexing information
- atezolizumab [MeSH Supplementary Concept]
Record concept(s)
- B7-H1 Antigen [MeSH concept]
Related MeSH Supplementary Concept(s)
- CD274 protein, human [MeSH Supplementary Concept]
- Cd274 protein, mouse [MeSH Supplementary Concept]
See also
- Immunoglobulin Domains [MeSH Descriptor]
See also (suggested by CISMeF)
- atezolizumab [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- Programmed cell death 1 ligand 1 (substance) [SNOMED CT concept]

Keyword's position in hierarchy(ies) :

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