Long Interspersed Nucleotide Element-1

Preferred Label : Long Interspersed Nucleotide Element-1;

NCIt synonyms : L-1 Element; L-1; L1-Element; LINE-1; L1;

NCIt definition : A long interspersed element (LINE) found in mammals. The LINE-1 element is the only active LINE in humans and is approximately 6,000 base pairs long. This nucleotide sequence consists of two non-overlapping open reading frames (ORF) flanked by a 5' untranslated region (UTR), which contains a strong RNA polymerase II promoter sequence, and target side duplications. The first ORF encodes a 500 amino acid, 40 kDa leucine zipper-containing RNA-binding protein. The second ORF encodes an 150 kDa protein that has endonuclease and reverse transcriptase activity. Increased LINE-1 copy number is associated with cancer and neuropathy.;

Details

Origin ID

C120020;

UMLS CUI

C0600472;

Anatomic structure is physical part of
- Cell [NCIt concept]
- Chromosome [NCIt concept]
Semantic type(s)
- Biologically Active Substance [UMLS semantic type]
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
UMLS correspondences (same concept)
- LINE-1 elements [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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