NCIt definition : An immunoglobulin G4 (IgG4), humanized monoclonal antibody directed against the immunosuppressive
ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274),
with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration,
adebrelimab specifically targets and binds to PD-L1, blocking its binding to and activation
of its receptor programmed death 1 (PD-1). This reverses T-cell inactivation caused
by PD-1/PD-L1 signaling and enhances the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor
immune response against PD-L1-expressing tumor cells. PD-L1 is overexpressed by many
human cancer cell types. PD-L1 binding to PD-1 on T-cells suppresses the immune system
and results in immune evasion. PD-1, a transmembrane protein belonging to the immunoglobulin
superfamily expressed on activated T-cells, is a negative regulator of the immune
system that limits the expansion and survival of CD8-positive T-cells.;
UNII : 1XBY50W1OX;
CAS number : 2247114-85-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2247114-85-6
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G-SRS /a ;
Semantic type(s)