Preferred Label : Anti-PD-L1/IL-15 Fusion Protein KD033;
NCIt definition : A fusion protein composed of a monoclonal antibody directed against the immunosuppressive
ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274)
fused to the immunostimulatory cytokine interleukin-15 (IL-15), with potential immunostimulatory
and antineoplastic activities. Upon administration of the anti-PD-L1/IL-15 fusion
protein KD033, the anti-PD-L1 antibody moiety specifically targets and binds to PD-L1
expressing cells in the tumor microenvironment (TME). In turn, IL-15 stimulates the
proliferation of natural killer (NK) cells, cytotoxic T-lymphocytes (CTLs) and memory
T-cells locally in the TME, which induces an anti-tumor immune response. This may
increase tumor cell killing and decrease tumor cell proliferation. IL-15 regulates
CD8 T and NK cell development, activation and proliferation. PD-L1, a transmembrane
protein, is expressed on the surface of antigen presenting cells (APCs) and on many
cancer cell types. PD-L1 binding to PD-1, a negative regulator of the immune system
on activated T-cells, limits the expansion and survival of CD8-positive T-cells, suppresses
the immune system and results in immune evasion.;
Molecule name : KD-033; KD 033;
NCI Metathesaurus CUI : CL1407359;
Origin ID : C173592;
UMLS CUI : C5418004;
Semantic type(s)
- concept_is_in_subset
- has_target
