Preferred Label : Oncolytic Virus CF33-expressing hNIS/Anti-PD-L1 Antibody;
NCIt synonyms : CF33-hNIS-antiPDL1; CF33 Expressing hNIS-Anti-PD-L1 Antibody;
NCIt definition : A genetically modified oncolytic virus (OV) composed of a replication competent orthopoxviral
chimera engineered to express the human sodium iodine symporter (hNIS) and a human
monoclonal antibody directed against the immunosuppressive ligand and immune checkpoint
inhibitor programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274;
CD274), with potential oncolytic, immunostimulating and antineoplastic activities
that can be used for radioimaging upon positron emission tomography (PET) and radiotherapeutic
applications. Upon subcutaneous (SC) intratumoral (IT) administration of the oncolytic
virus CF33-expressing hNIS/anti-PD-L1 antibody, the oncolytic virus specifically infects
and replicates in tumor cells causing viral-mediated tumor cell lysis. The released
virus particles, in turn, infect and replicate in neighboring tumor cells. Tumor antigens
released from the lysed tumor cells also activate the immune system to induce a tumor-specific
systemic immune and cytotoxic T-lymphocyte (CTL) response, thereby killing nearby
non-infected tumor cells. In addition, the anti-PD-L1 antibody produced by the infected
tumor cells targets and binds to PD-L1, blocking its binding to and activation of
its receptor programmed cell death 1 (PD-1; cluster of differentiation 279; CD279),
a transmembrane protein and negative regulator of the immune system, expressed on
activated T-cells. This reverses T-cell inactivation caused by PD-1/PD-L1 signaling
and enhances the CTL-mediated anti-tumor immune response against PD-L1-expressing
tumor cells, thereby further killing tumor cells. Upon subsequent administration of
certain iodine-containing imaging agents, hNIS expression by the infected tumor cells
allows visualization and tracking of viral biodistribution, and analysis and quantification
of CF33-infected tumor cells by PET. Also, administration of iodine I 131 results
in its uptake by hNIS-expressing tumor cells, which may result in the selective accumulation
of a cytotoxic dose of radiation in tumor cells while sparing adjacent normal tissue.;
NCI Metathesaurus CUI : CL1663692;
Origin ID : C181094;
UMLS CUI : C5556843;
Semantic type(s)
- concept_is_in_subset
- has_target
