NCIt definition : A monoclonal antibody directed against programmed cell death-1 ligand 1 (PD-L1) with
immune checkpoint inhibitory and potential antineoplastic activities. Upon administration,
lodapolimab binds to PD-L1 and prevents the interaction of PD-L1 with its receptor
programmed cell death protein 1 (PD-1). This inhibits the activation of PD-1 and its
downstream signaling pathways, which may enhance the T-cell-mediated immune response
to neoplasms and reverse T-cell inactivation. PD-L1 is overexpressed by many human
cancer cell types. PD-L1 binding to PD-1 on T-cells suppresses the immune system and
results in immune evasion. PD-1, a transmembrane protein expressed on activated T-cells,
is a negative regulator of the immune system that limits the expansion and survival
of CD8 T-cells.;
Semantic type(s)