" /> Envafolimab - CISMeF





Preferred Label : Envafolimab;

NCIt synonyms : Anti-PD-L1 MoAb KN035;

NCIt definition : An injectable formulation of a monoclonal antibody directed against programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with immune checkpoint inhibitory and potential antineoplastic activities. Upon subcutaneous administration, envafolimab binds to PD-L1, blocking its binding to and activation of its receptor programmed death 1 (PD-1), which may enhance the T-cell-mediated immune response to neoplasms and reverse T-cell inactivation. PD-L1 is overexpressed by many human cancer cell types. PD-L1 binding to PD-1 on T-cells suppresses the immune system and results in immune evasion. PD-1, a transmembrane protein expressed on activated T-cells, is a negative regulator of the immune system that limits the expansion and survival of CD8 T cells.;

UNII : ES1M06M6QH;

CAS number : 2102192-68-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2102192-68-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : KN035; KN 035;

NCI Metathesaurus CUI : CL512904;

Codes from synonyms : 18741;

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15/05/2024


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