Preferred Label : Fluorine F18 BMS-986192;
NCIt synonyms : 18F-labeled Adnectin BMS-986192; Fluorine F18 BMS 986192; Fluorine F18 BMS986192; 18F-BMS-986192; 18F-labeled Anti-PD-L1 Adnectin BMS 986192;
NCIt definition : A radiotracer composed of the adnectin BMS-986192, a fibronectin-based protein that
targets programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274),
labeled with the radioisotope fluorine F 18, with potential use for assessing PD-L1
tumor antigen expression using positron emission tomography (PET). Upon administration
of fluorine F 18 BMS-986192, the BMS-986192 moiety specifically targets and binds
to PD-L1 expressed on certain tumor cells. Upon PET imaging, the radiotracer can be
visualized and the extent of PD-L1 expression can be assessed. Adnectins, a protein
family derived from the 10th type III domain of human fibronectin with high-affinity
targeting capabilities, have favorable physicochemical properties, such as small size,
high stability, high affinity and specificity.;
NCI Metathesaurus CUI : CL1907410;
Origin ID : C200394;
UMLS CUI : C5856221;
Semantic type(s)
- concept_is_in_subset
- has_target
