" /> Tagitanlimab - CISMeF





Preferred Label : Tagitanlimab;

NCIt synonyms : Anti-PD-L1 Monoclonal Antibody A167;

NCIt definition : A humanized monoclonal antibody directed against the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, tagitanlimab specifically targets and binds to PD-L1, blocking its binding to and activation of its receptor programmed cell death 1 (PD-1; cluster of differentiation 279; CD279). This reverses T-cell inactivation caused by PD-1/PD-L1 signaling and enhances the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against PD-L1-expressing tumor cells. PD-L1 is overexpressed by many human cancer cell types. PD-L1 binding to PD-1 on T-cells suppresses the immune system and results in immune evasion. PD-1, a transmembrane protein belonging to the immunoglobulin superfamily (IgSF) expressed on activated T-cells, is a negative regulator of the immune system that limits the expansion and survival of CD8-positive T-cells.;

UNII : GUY458P83P;

CAS number : 2417649-97-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2417649-97-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : A-167; KL A167; KL-A167; A 167;

NCI Metathesaurus CUI : CL977261;

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15/05/2024


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