NCIt definition : A half-life extended (HLE) human bispecific T-cell engager (BiTE) antibody targeting
the CD3 antigen expressed on T-lymphocytes and the cell surface protein claudin 6
(CLDN6; CLDN-6), with potential immunostimulating and antineoplastic activities. Upon
intravenous administration, anti-CLDN6/CD3 BiTE antibody AMG 794 targets and binds
to both CD3 expressed on T-cells and CLDN6 expressed on tumor cells. This activates
and redirects cytotoxic T-lymphocytes (CTLs) to CLDN6-expressing tumor cells, produces
cytokines and leads to enhanced CTL-mediated elimination of CLDN6-expressing tumor
cells. CLDN6, a tight-junction protein and embryonic antigen, is expressed on a variety
of tumor cells but is not expressed on normal, healthy adult cells.;
Semantic type(s)