Preferred Label : Engineered Toxin Body Targeting PD-L1 MT-6402;
NCIt synonyms : Immunotoxin MT-6402; Anti-PD-L1-engineered Toxin Body MT-6402; ETB Targeting PD-L1 MT-6402;
NCIt definition : An engineered toxin body (ETB) composed of a single chain variable fragment (scFv)
targeting the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster
of differentiation 274; CD274), fused to the enzymatically active de-immunized, ribosome-inactivating
cytotoxic payload Shiga-like toxin-A subunit (SLTA) and a class I antigen derived
from the human cytomegalovirus (CMV) phosphoprotein pp65, with potential immunomodulatory
and antineoplastic activities. Upon administration, the scFv moiety of ETB targeting
PD-L1 MT-6402 specifically targets and binds to PD-L1-expressing tumor and immune
cells in the tumor microenvironment (TME). Upon internalization, the SLTA moiety is
released and acts as an N-glycosidase, which binds to and cleaves an adenine nucleobase
in the 28S RNA component of the 60S subunit of ribosomes and prevents ribosome activity.
This inhibits protein synthesis and leads to apoptosis in PD-L1-expressing tumor and
immune cells in the TME. In addition, MT-6402 delivers the foreign class I antigen
derived from CMV pp65 peptide. This may result in a CMV-specific immune response against
PD-L1-expressing tumor and immune cells in the TME. PD-L1, a transmembrane protein,
is expressed on the surface of certain immune cells and on many cancer cell types.
PD-L1 binding to PD-1, a negative regulator of the immune system on activated T-cells,
limits the expansion and survival of CD8-positive T-cells, suppresses the immune system
and results in immune evasion.;
Molecule name : MT 6402; MT-6402;
NCI Metathesaurus CUI : CL1664900;
Origin ID : C181982;
UMLS CUI : C5557402;
Semantic type(s)
- concept_is_in_subset
- has_target
