Preferred Label : Anti-ILT4/Anti-PD-L1 Bispecific Antibody SPX-303;
NCIt synonyms : Anti-ILT4/PD-L1 Bispecific Antibody SPX-303; Anti-PD-L1/Anti-LILRB2 Bispecific Antibody SPX-303; Anti-LILRB2/Anti-PD-L1 Bispecific Antibody SPX-303; LILRB2 x PD-L1 Bispecific Antibody SPX-303; Anti-LILRB2/PD-L1 Bispecific Antibody SPX-303;
NCIt definition : A bispecific antibody directed against both the inhibitory immune checkpoint receptor
immunoglobulin-like transcript 4 (ILT4; leukocyte immunoglobulin-like receptor subfamily
B member 2; LILRB2; lymphocyte immunoglobulin-like receptor 2; LIR2; monocyte/macrophage
immunoglobulin-like receptor 10; MIR-10; CD85d) and the immunosuppressive ligand programmed
cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential
immune checkpoint inhibitory, immunostimulatory and antineoplastic activities. Upon
administration, anti-ILT4/anti-PD-L1 bispecific antibody SPX-303 targets and binds
to both ILT4 and PD-L1. The binding of SPX-303 to ILT4 prevents activation by its
ligands, including the major histocompatibility complex class I (MHC I) molecules
human leukocyte antigen (HLA)-A, HLA-B, HLA-C and HLA-G, and inhibits ILT4-mediated
signaling. This abrogates the immunosuppressive activities of ILT4 in the tumor microenvironment
(TME), activates the expression of pro-inflammatory cytokines, including GM-CSF and
tumor necrosis factor alpha (TNFalpha), and enhances a cytotoxic T-lymphocyte (CTL)-mediated
anti-tumor immune response. The binding of SPX-303 to PD-L1 prevents the binding to
its receptor, programmed cell death protein 1 (PD-1, CD279), inhibits the PD-1/PD-L1-mediated
signaling, and inhibits the PD-1/PD-L1-mediated downregulation of T-cell activation
and proliferation. This restores and enhances a CTL-mediated immune response against
tumor cells. PD-L1, which is overexpressed in many human cancer cell types, plays
an important role in the downregulation of the immune system and tumor evasion from
host immunity. ILT4, a transmembrane protein and inhibitory member of the immunoglobulin-like
transcript (ILT) family of proteins, is expressed primarily by myeloid cells, including
monocytes, macrophages, dendritic cells (DCs) and granulocytes, and certain tumor
cells; it also plays a role in tumor evasion.;
Molecule name : SPX 303; SPX-303;
Origin ID : C208071;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
