NCIt definition : A humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against the immunosuppressive
ligand programmed cell death-1 (PD-L1; cluster of differentiation 274; CD274), with
potential immune checkpoint inhibitory and antineoplastic activities. Upon administration,
benmelstobart specifically targets and binds to PD-L1, preventing the binding and
subsequent activation of its receptor, programmed cell death 1 (PD-1; PDCD1; CD279;
programmed death-1). This reverses T-cell inactivation caused by PD-L1/PD-1 signaling,
increases T-cell expansion and enhances the cytotoxic T-lymphocyte (CTL)-mediated
anti-tumor immune response against PD-L1-expressing tumor cells. PD-L1, a transmembrane
protein expressed on activated T-cells, is overexpressed in some cancer types and
plays a significant role in immune evasion by tumor cells.;
UNII : B25CF42QKP;
CAS number : 2303884-58-2;
Molecule name : CBT 502; TQB-2450; CBT-502; TQB 2450; APL502;
Semantic type(s)