Preferred Label : Autologous 1928T2z CAR T-cells WZTL-002;
NCIt synonyms : Autologous Third-generation Anti-CD19 Chimeric Antigen Receptor T-cells WZTL-002; Autologous 1928T2z CAR-T-lymphocytes WZTL-002; Autologous CAR T-cells WZTL-002; AntiCD19 CAR-CD28zeta-TLR2-expressing T-cells WZTL-002;
NCIt definition : A preparation of autologous, third-generation T-lymphocytes that have been transduced
with a self-inactivating lentiviral vector to express a chimeric antigen receptor
(CAR) containing a single-chain variable fragment (scFv) from the monoclonal antibody
FMC63, which is directed against the CD19 antigen, and linked to the co-stimulatory
intracellular signaling domains of CD28 and the zeta chain of the TCR/CD3 complex
(CD3-zeta) (CD28zeta; CD28z), and the Toll/interleukin-1 receptor (TIR) domain from
Toll-like receptor 2 (TLR2) as an additional co-stimulatory domain, with potential
immunostimulating and antineoplastic activities. Upon administration, the autologous
1928T2z CAR T-cells WZTL-002 specifically recognize and bind to CD19-expressing tumor
cells, resulting in specific T-cell-mediated tumor cell lysis. CD19 antigen is a B-cell
specific cell surface antigen, which is expressed in all B-cell lineage malignancies
and normal B-cells. In addition to CD28 and CD3zeta, the TLR2-TIR domain provides
co-stimulatory activity and may enhance the cytotoxic effect and anti-tumor activity
of the CAR T-cells. The TIR domain from TLR2 mediates the intracellular signaling
of TLR2; TLR2 stimulation enhances T-cell activation, proliferation and cytokine production.;
Molecule name : WZTL-002; WZTL 002;
NCI Metathesaurus CUI : CL1383047;
Origin ID : C170905;
UMLS CUI : C5417828;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
