Preferred Label : Lutetium Lu 177 Anti-PD-L1 Nanobody RAD204;
NCIt synonyms : 177Lu-RAD204; Lutetium Lu 177 Anti-PD-L1 Nanobody RAD-204; [Lu-177]RAD204; 177Lu-Anti-PD-L1 Single Domain Antibody RAD204; Lutetium Lu 177-labeled Anti-PD-L1 Nanobody RAD204; 177Lu-RAD-204;
NCIt definition : A radioimmunoconjugate composed of a nanobody directed against programmed cell death-1
ligand 1 (PD-L1; cluster of differentiation 274; CD274) and labeled with the beta-emitting
radioisotope lutetium Lu 177, with potential imaging activity of PD-L1 tumor antigen
expression during single-photon emission computerized tomography/computerized tomography
(SPECT/CT) and with potential antineoplastic activity. Upon administration of lutetium
Lu 177 anti-PD-L1 nanobody RAD204, the RAD204 moiety targets and binds to the PD-L1
expressed on certain tumor cells. Upon uptake and imaging, the radioisotope moiety
can be visualized and the extent of PD-L1 expression can be assessed. Also, this radioconjugate
specifically delivers a cytotoxic dose of beta radiation to PD-L1-expressing tumor
cells. PD-L1, a transmembrane protein, is overexpressed on the surface of many cancer
cell types.;
Origin ID : C211548;
concept_is_in_subset
- has_target
