Preferred Label : Anti-PD-L1/Anti-OX40 Bispecific Antibody EMB-09;
NCIt synonyms : Anti-PD-L1/OX40 Bispecific Antibody EMB-09; PD-L1xOX40 Bispecific Antibody EMB-09; FIT-Ig Bispecific Antibody EMB-09; Fabs-In-Tandem Immunoglobulin Bispecific Antibody EMB-09;
NCIt definition : A tetravalent, bispecific antibody directed against both the immunosuppressive ligand
programmed cell death-1 (PD-L1; cluster of differentiation 274; CD274) and the co-stimulatory
receptor OX40 (CD134; TNFRSF4), with potential immune checkpoint inhibitory, immunostimulatory
and antineoplastic activities. Upon administration, anti-PD-L1/anti-OX40 bispecific
antibody EMB-09 binds to PD-L1 expressed on tumor cells, and simultaneously binds
to and activates OX40 on activated T-cells. The binding of EMB-09 to PD-L1 blocks
its binding to and activation of its receptor, programmed cell death 1 (PD-1; cluster
of differentiation 279; CD279). This reverses T-cell inactivation caused by PD-1/PD-L1
signaling and enhances the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune
response against PD-L1-expressing tumor cells. The binding of EMB-09 to OX40 and the
activation of OX40 induces the proliferation of memory and effector T-lymphocytes,
which also enhances the anti-tumor immune response against PD-L1-expressing tumor
cells. PD-L1 is overexpressed by many human cancer cell types. PD-L1 binding to PD-1,
a transmembrane protein belonging to the immunoglobulin superfamily (IgSF) that is
expressed on activated T-cells, suppresses the immune system and results in immune
evasion. OX40, a cell surface glycoprotein and member of the tumor necrosis factor
(TNF) receptor superfamily, is mainly expressed on activated T-cells and provides
a co-stimulatory signal for the proliferation and survival of activated T-cells.;
Molecule name : EMB 09; EMB-09;
NCI Metathesaurus CUI : CL1791984;
Origin ID : C187101;
UMLS CUI : C5706345;
Semantic type(s)
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
