Preferred Label : Emfizatamab;
NCIt synonyms : CD19 x CD3 x PD-L1 x 4-1BB Tetra-specific Antibody GNC-038; Anti-CD19/CD3/PD-L1/4-1BB Tetra-specific Antibody GNC-038;
NCIt definition : An anti-CD19/anti-CD3/anti-PD-L1/anti-4-1BB tetra-specific antibody, with potential
immunostimulatory and antineoplastic activities. Upon administration, emfizatamab
targets and binds to the tumor-associated antigen (TAA) CD19 overexpressed on the
surface of B-cells, the immunosuppressive ligand programmed cell death-1 ligand 1
(PD-L1; cluster of differentiation 274; CD274) expressed on tumor cells, the T-cell
surface antigen CD3 and the costimulatory receptor 4-1BB (CD137; tumor necrosis factor
receptor superfamily member 9; TNFRSF9) expressed on a variety of leukocyte subsets
including activated T-lymphocytes. This may crosslink CD19-expressing tumor B-cells
and cytotoxic T-lymphocytes (CTLs) and result in a potent CTL-mediated cell lysis
of CD19-expressing B-lymphocytes. In addition, 4-1BB binding results in T-cell co-stimulation
and enhanced anti-tumor activity. At the same time, GNC-038 prevents PD-L1 from binding
to and activating its receptor, programmed cell death 1 (PD-1; PDCD1; CD279; programmed
death-1). This abrogates T-cell inhibition, activates antigen-specific T-lymphocytes
and enhances CTL-mediated tumor cell lysis, which may lead to a reduction in tumor
growth. PD-L1 binding to PD-1 on activated T-cells inhibits the expansion and survival
of CD8-positive T-cells, suppresses the immune system and results in immune evasion.
4-1BB, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is
an inducible costimulatory receptor that plays a key role in T-cell proliferation,
survival and cytolytic activity. CD19, a B-cell specific membrane antigen, is expressed
during normal B-cell development and on B-cell malignancies.;
UNII : FB8PCJ9N3H;
CAS number : 2559704-23-1;
Molecule name : GNC 038; GNC-038;
NCI Metathesaurus CUI : CL1648119;
Origin ID : C178448;
UMLS CUI : C5706703;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
