NCIt definition : An immunoglobulin G1 (IgG1), human monoclonal antibody directed against the immunosuppressive
ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274),
with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration,
cosibelimab specifically targets and binds to PD-L1, blocking its binding to and activation
of its receptor programmed cell death protein 1 (PD-1; PDCD1; CD279; programmed death-1).
This reverses T-cell inactivation caused by PD-1/PD-L1 signaling and enhances the
cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against PD-L1-expressing
tumor cells. PD-L1 is overexpressed by many human cancer cell types. PD-L1 binding
to PD-1 on T-cells suppresses the immune system and results in immune evasion. PD-1,
a transmembrane protein belonging to the immunoglobulin superfamily expressed on activated
T-cells, is a negative regulator of the immune system that limits the expansion and
survival of CD8-positive T-cells.;
Semantic type(s)