Preferred Label : PD-L1/PD-L2/VISTA Antagonist CA-170;
NCIt synonyms : PD-L1/PD-L2/VISTA Checkpoint Antagonist CA-170; Aurigene 1;
NCIt related terms : CA-170;
NCIt definition : An orally bioavailable small molecule inhibitor of the immune checkpoint regulatory
proteins programmed cell death ligand-1 (PD-L1; B7-H1; CD274), PD-L2, and V-domain
immunoglobulin (Ig) suppressor of T-cell activation (VISTA; programmed death 1 homolog;
PD1H; PD-1H), with potential negative immune checkpoint regulatory and antineoplastic
activities. Upon oral administration, PD-L1/PD-L2/VISTA antagonist CA-170 targets
and binds to PD-L1, PD-L2 and VISTA. This inhibits PD-L1/PD-L2/VISTA-mediated signaling,
abrogates the PD-L1-, PD-L2- and VISTA-induced suppression of T-lymphocyte immune
responses, enhances cytotoxic T-cell proliferation and activation against tumor cells,
increases cytokine production by T-cells, and inhibits tumor cell growth. PD-L1, PD-L2
and VISTA, negative checkpoint molecules of immune activation, play key roles in the
suppression of T-cell functions.;
UNII : 646MN6KQ16;
CAS number : 1673534-76-3;
Molecule name : CA-170; AUPM 170;
NCI Metathesaurus CUI : CL512601;
Origin ID : C129594;
UMLS CUI : C4330914;
Semantic type(s)
- concept_is_in_subset
- has_target
