Preferred Label : Programmed Cell Death 1 Ligand 2;
NCIt synonyms : CD273; PD1 Ligand 2 Protein; B7DC; Butyrophilin B7-DC; Programmed Death Ligand 2 Protein; Programmed Death Ligand 2; PDL2; B7-DC; PDCD1 Ligand 2; PDCD1 Ligand 2 Protein; PDCD1LG2; PD-L2; PD-1-Ligand 2; CD273 Antigen; PDCD1L2; B7 Dendritic Cell Molecule; Programmed Death Ligand-2 Protein; PD-1 Ligand 2;
NCIt definition : Programmed cell death 1 ligand 2 (273 aa, 31 kDa) is encoded by the human PDCD1LG2
gene. This protein is involved in the modulation of both T-cell proliferation and
cytokine production.;
NCIt note : Widely expressed (highest in placenta, heart, pancreas, lung, and liver) by human
PDCD1LG2 Gene, 273 aa 31-kDa Programmed Death Ligand 2 Protein is 70% identical to
mouse Pdl2 protein and contains a signal sequence, IgV- and IgC-like domains, a transmembrane
region, and a cytoplasmic region. Gamma-interferon stimulates PDCD1LG2 expression
in monocytes. The IgV domain appears to bind to PDCD1, but not to CTLA4, CD28, or
ICOS. Stimulation with anti-CD3 and Pdl2, or Pdl1, inhibits proliferation of mouse
T cells and cytokine production. At low anti-CD3 concentrations, mouse Pdl2 preferentially
co-stimulates CD4-positive (Th1) T-cell proliferation and Ifng production.;
Origin ID : C45438;
UMLS CUI : C1705357;
OMIM relation
- Semantic type(s)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_plays_role_in_biological_process
- is_target
