NCIt definition : A recombinant form of the monoclonal IgM antibody M12 isolated from a Waldenstrom
macroglobulinaemia patient (rHIgM12) with potential immunomodulating activity. B7-DC
cross-linking antibody rHIgM12B7 binds and crosslinks the B7 co-stimulatory family
member B7-DC (PD-L2) on dendritic cells (DCs), antigen presenting cells (APCs) that
play a crucial role in the human immune response. This results in enhanced activation
of DCs; enhanced antigen-presenting activity; and increased production of immunomodulatory
cytokines (especially interleukin 12); and may potentiate a specific cytotoxic T lymphocyte
(CTL) response against Waldenstrom macroglobulinaemia B cells.;
Semantic type(s)