NCIt synonyms : Anti-PD-L1/VEGF Bispecific Antibody Fusion Protein B1962; PD-L1/VEGF Bispecific Antibody Fusion Protein B1962; PD-L1 x VEGF Bispecific Antibody Fusion Protein B1962; Anti-PD-L1/Anti-VEGF Bispecific Antibody Fusion Protein B1962;
NCIt definition : A bispecific antibody composed of an immunoglobulin G1 (IgG1) monoclonal antibody
targeting the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster
of differentiation 274; CD274) and fused to anti-vascular endothelial growth factor
(VEGF) protein, with potential immune checkpoint inhibitory, anti-angiogenic and antineoplastic
activities. Upon administration, anti-PD-L1/anti-VEGF bispecific antibody AP505 targets
and simultaneously binds to both PD-L1 and VEGF expressed on tumor cells. This prevents
the binding of PD-L1 to its receptor, programmed cell death protein 1 (PD-1, CD279),
inhibits the PD-1-mediated signaling, and inhibits the PD-1-mediated downregulation
of T-cell activation and proliferation. This restores and enhances a cytotoxic T-lymphocyte
(CTL)-mediated immune response against VEGF-expressing tumor cells. The binding of
AP505 to VEGF prevents the binding of VEGF to its receptor VEGFR, abrogates VEGF/VEGFR-mediated
signaling and may lead to the inhibition of vascular endothelial cell proliferation.
The inhibition of tumor angiogenesis may further decrease tumor cell proliferation
and prevent metastasis. PD-L1 is overexpressed in many human cancer cell types and
plays an important role in the downregulation of the immune system and tumor evasion
from host immunity. VEGF is overexpressed in a variety of cancers and is associated
with increased invasiveness and decreased survival.;
Semantic type(s)