Preferred Label : PD-L1 Inhibitor AN4005;
NCIt definition : An orally available, small molecule inhibitor of the immunosuppressive ligand programmed
cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential
immune checkpoint inhibitory and antineoplastic activities. Upon oral administration,
PD-L1 inhibitor AN4005 specifically targets and binds to PD-L1 expressed on tumor
cells, thereby preventing the binding of PD-L1 to and subsequent activation of its
receptor programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1). This reverses
T-cell inactivation caused by PD-L1/PD-1 signaling, increases T-cell expansion and
enhances the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against
PD-L1-expressing tumor cells. PD-L1, a transmembrane protein expressed on activated
T-cells, is overexpressed in some cancer types and plays a significant role in immune
evasion by tumor cells.;
Molecule name : AN 4005; AN-4005;
NCI Metathesaurus CUI : CL1791914;
Origin ID : C187159;
UMLS CUI : C5706382;
Semantic type(s)
- concept_is_in_subset
- has_target
