NCIt definition : A formulation composed of nanoparticle albumin-bound (nab) paclitaxel, which is an
albumin-stabilized nanoparticle containing the natural taxane paclitaxel, complexed
with danburstotug, a human monoclonal antibody directed against the immunosuppressive
ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274),
with potential antineoplastic activity. Upon administration of nab-paclitaxel/danburstotug
complex AP160, the danburstotug moiety specifically binds to PD-L1 and targets this
formulation to PD-L1-positive tumor cells. In turn, paclitaxel binds to and stabilizes
microtubules, which prevents depolymerization and inhibits cellular motility, mitosis,
and replication. This leads to cell death of PD-L1-expressing tumor cells that were
targeted by this agent. The combination of albumin-stabilization and targeting by
the danburstotug moiety allows for higher efficacy and decreased paclitaxel-induced
toxicity as it specifically targets PD-L1-expressing tumor cells. PD-L1 is overexpressed
by many human cancer cell types.;
Semantic type(s)