Preferred Label : PD-L1 Inhibitor ABSK043;
NCIt synonyms : PD-1 Ligand 1 Inhibitor IABSK043;
NCIt definition : An orally available, small molecule inhibitor of the immunosuppressive ligand programmed
cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential
immune checkpoint inhibitory and antineoplastic activities. Upon oral administration,
PD-L1 inhibitor ABSK043 specifically targets and binds to PD-L1 expressed on tumor
cells, leading to internalization and preventing the binding to and subsequent activation
of its receptor, programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1).
This reverses T-cell inactivation caused by PD-L1/PD-1 signaling, increases T-cell
expansion and enhances the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune
response against PD-L1-expressing tumor cells. PD-L1, a transmembrane protein expressed
on activated T-cells, is overexpressed in some cancer types and plays a significant
role in immune evasion by tumor cells.;
Molecule name : ABSK 043; ABSK-043;
NCI Metathesaurus CUI : CL1664653;
Origin ID : C181748;
UMLS CUI : C5557243;
Semantic type(s)
- concept_is_in_subset
- has_target
