Preferred Label : Anti-PD-L1/TIM-3 Bispecific Antibody LY3415244;
NCIt related terms : LY-3415244;
NCIt definition : A bispecific antibody directed against the inhibitory T-cell receptor T-cell immunoglobulin
and mucin domain-containing protein 3 (TIM-3; TIM3; hepatitis A virus cellular receptor
2; HAVCR2) and the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1;
cluster of differentiation 274; CD274), with potential immune checkpoint inhibitory
and antineoplastic activities. Upon administration, LY3415244 simultaneously targets
and binds to TIM-3 expressed on certain T-cells, including tumor-infiltrating lymphocytes
(TILs), and PD-L1 expressed on tumor cells. This blocks the interaction of TIM-3 with
some of its physiologic ligands and prevents PD-L1 from binding to and activating
its receptor, programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1). This
abrogates T-cell inhibition, activates antigen-specific T-lymphocytes and enhances
cytotoxic T-cell-mediated tumor cell lysis, which may lead to a reduction in tumor
growth. TIM-3, a transmembrane protein and immune checkpoint receptor, is often co-expressed
with PD-1 on tumor-antigen-specific T-cells. PD-L1 binding to PD-1 on activated T-cells
inhibits the expansion and survival of CD8-positive T-cells, suppresses the immune
system and results in immune evasion.;
UNII : 603H2FWG4N;
Molecule name : LY 3415244; LY3415244;
NCI Metathesaurus CUI : CL936018;
Origin ID : C157058;
UMLS CUI : C4745242;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
