transforming growth factor beta

Preferred Label : transforming growth factor beta;

MeSH definition : A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.;

MeSH synonym : tgfbeta; tgf-beta; platelet transforming growth factor; bone derived transforming growth factor; growth factor, milk; factor, milk growth; milk growth factor; bone-derived transforming growth factor;

Wikipedia link : https://en.wikipedia.org/wiki/Transforming growth factor beta;

Is substance : O;

Details

Origin ID

D016212;

UMLS CUI

C0040690;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Transforming Growth Factor-Beta Superfamily [NCIt concept]
- Transforming growth factor beta [LOINC component]
Indexing information
- CKS 25 [MeSH Supplementary Concept]
- DAF-14 protein, C elegans [MeSH Supplementary Concept]
- DAF-3 protein, C elegans [MeSH Supplementary Concept]
- GDF3 protein, Xenopus [MeSH Supplementary Concept]
- Gdf11 protein, rat [MeSH Supplementary Concept]
- Gdf7 protein, mouse [MeSH Supplementary Concept]
- Med protein, Drosophila [MeSH Supplementary Concept]
- Ndr2 protein, vertebrate [MeSH Supplementary Concept]
- Receptor, Transforming Growth Factor-beta Type II [MeSH Descriptor]
- SMAD9 protein, human [MeSH Supplementary Concept]
- STK38L protein, Xenopus [MeSH Supplementary Concept]
- Smad4 protein, mouse [MeSH Supplementary Concept]
- Smad4 protein, rat [MeSH Supplementary Concept]
- Smad8 protein, xenopus [MeSH Supplementary Concept]
- Smad9 protein, mouse [MeSH Supplementary Concept]
- Smad9 protein, rat [MeSH Supplementary Concept]
- cartilage-derived morphogenetic protein-3 protein, mouse [MeSH Supplementary Concept]
- cartilage-derived-morphogenetic protein-2 [MeSH Supplementary Concept]
- dpp protein, drosophila [MeSH Supplementary Concept]
- ethyl 4-(4-tert-butylphenyl)-2-methyl-5-oxo-7-(n-propyl)-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate [MeSH Supplementary Concept]
- growth differentiation factor 7 [MeSH Supplementary Concept]
- mav protein, Drosophila [MeSH Supplementary Concept]
- ndr1 protein, zebrafish [MeSH Supplementary Concept]
Record concept(s)
- transforming growth factor beta [MeSH concept]
Related MeSH Supplementary Concept(s)
- ADMP2 protein, xenopus [MeSH Supplementary Concept]
- As60A protein, anopheles stephensi [MeSH Supplementary Concept]
- DAF-7 protein, C elegans [MeSH Supplementary Concept]
- Dbl-1 protein, C elegans [MeSH Supplementary Concept]
- GDF1 protein, Xenopus [MeSH Supplementary Concept]
- Gdf3 protein, zebrafish [MeSH Supplementary Concept]
- NODAL protein, Xenopus [MeSH Supplementary Concept]
- SCW protein, Drosophila [MeSH Supplementary Concept]
- TGF-beta5 protein, xenopus laevis [MeSH Supplementary Concept]
- TGFBI protein (611-642), human [MeSH Supplementary Concept]
- UNC-129 protein, C elegans [MeSH Supplementary Concept]
- betaIG-H3 protein [MeSH Supplementary Concept]
- fugacin [MeSH Supplementary Concept]
- gbb protein, drosophila [MeSH Supplementary Concept]
- gonadal soma-derived factor, zebrafish [MeSH Supplementary Concept]
- latency-associated propeptide, TGF-beta [MeSH Supplementary Concept]
- myo protein, Drosophila [MeSH Supplementary Concept]
- nodal3.1 protein, Xenopus [MeSH Supplementary Concept]
- recombinant human bone morphogenetic protein-2 [MeSH Supplementary Concept]
- sara protein, drosophila [MeSH Supplementary Concept]
- transforming growth factor beta1.2 [MeSH Supplementary Concept]
- transforming growth factor beta2.3 [MeSH Supplementary Concept]
- transforming growth factor beta4 [MeSH Supplementary Concept]
- univin [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Transforming Growth Factor-Beta Superfamily [NCIt concept]
- Transforming growth factor beta [LOINC component]

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