" /> Glial Cell Line-Derived Neurotrophic Factor - CISMeF





Preferred Label : Glial Cell Line-Derived Neurotrophic Factor;

NCIt synonyms : Glial Cell-Line Derived Neurotrophic Factor; GDNF; ATF; Glial Derived Neurotrophic Factor; Glial Cell Line Derived Neurotrophic Factor; hGDNF; Astrocyte-Derived Trophic Factor;

NCIt definition : Glial cell line-derived neurotrophic factor (211 aa, 24 kDa) is encoded by the human GDNF gene. This protein plays a role in the modulation of the survival and differentiation of dopaminergic neurons.;

NCIt note : Glial cell derived neurotrophic factor enhances the survival and morphological differentiation of dopaminergic neurons and increases their uptake of dopamine. GDNF can rescue motor neurons from programmed cell death and death caused by axotomy. GDNF is a possible treatment for Parkinson disease because it can protect cells from the effect of the neurotoxin MPTP. GDNF is a ligand for the RET gene product and may contribute to Hirschsprung disease when mutated and combined with a mutant RET. (LocusLink); The active form of glial cell line-derived neurotrophic factor is released from the precursor after proteolytic removal of 75 N-terminal amino acids. The active form is a secreted protein which occurs as a disulfide-linked homodimer. (UniProt);

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04/05/2025


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