Anti-TGF-beta Monoclonal Antibody SAR-439459

Preferred Label : Anti-TGF-beta Monoclonal Antibody SAR-439459;

NCIt synonyms : Anti-TGFb SAR-439459; Anti-transforming Growth Factor-beta mAb SAR439459;

NCIt related terms : SAR-439459;

NCIt definition : A monoclonal antibody (mAb) directed against human transforming growth factor beta (TGF-beta; TGFb), with potential antineoplastic activity. Upon administration, anti-TGF-beta monoclonal antibody SAR-439459 specifically targets and binds to TGF-beta, thereby preventing the activation of TGF-beta-mediated signaling pathways. This may inhibit the proliferation of tumor cells in which TGF-beta is overactivated. TGF-beta, a pro-inflammatory mediator that is mutated and/or overexpressed in a variety of cancer cell types, is involved in cancer cell proliferation and migration, and in tumor progression.;

UNII : 7EFI23P78R;

Molecule name : SAR 439459; SAR-439459;

NCI Metathesaurus CUI : CL544827;

Details

Origin ID

C146862;

UMLS CUI

C4687517;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Transforming Growth Factor-Beta Superfamily [NCIt concept]

Keyword's position in hierarchy(ies) :

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