Recombinant Transforming Growth Factor-Beta

Preferred Label : Recombinant Transforming Growth Factor-Beta;

NCIt synonyms : Therapeutic Milk Growth Factor; TGF-Beta; Bone-Derived Transforming Growth Factor; Therapeutic TGF-Beta; rTGF-Beta; Therapeutic TGF B; Therapeutic Transforming Growth Factor-Beta;

NCIt definition : A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine transforming growth factor-beta (TGF-beta) with proapoptotic and antineoplastic properties. TGF-beta may suppress tumor cell growth by decreasing the expression of cyclin D1, a cell cycle regulatory protein, and downregulating the expression of the oncogene c-myc. This agent is also involved in T cell-mediated immunosuppression by CD4 CD25 T cells, which permits cancer cells to evade immune surveillance. (NCI04);

Details

Origin ID

C898;

UMLS CUI

C1527196;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_related_to_endogenous_product
- Transforming Growth Factor-Beta Superfamily [NCIt concept]

Keyword's position in hierarchy(ies) :

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