" /> Cetuximab - CISMeF





Preferred Label : Cetuximab;

NCIt synonyms : Chimeric Anti-EGFR Monoclonal Antibody; Chimeric Monoclonal Antibody C225; Chimeric MoAb C225; Cetuximab Biosimilar CMAB009; Cetuximab Biosimilar CDP-1; Cetuximab Biosimilar KL 140;

NCIt related terms : Erbitux;

NCIt definition : A recombinant, chimeric monoclonal antibody directed against the epidermal growth factor (EGFR) with antineoplastic activity. Cetuximab binds to the extracellular domain of the EGFR, thereby preventing the activation and subsequent dimerization of the receptor; the decrease in receptor activation and dimerization may result in an inhibition in signal transduction and anti-proliferative effects. This agent may inhibit EGFR-dependent primary tumor growth and metastasis. EGFR is overexpressed on the cell surfaces of various solid tumors.;

Alternative definition : NCI-GLOSS: A monoclonal antibody used to treat certain types of head and neck cancer, and colorectal cancer that has spread to other parts of the body. It is also being studied in the treatment of other types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to cancer cells. Erbitux binds to the epidermal growth factor receptor (EGFR), which is found on the surface of some types of cancer cells.;

UNII : PQX0D8J21J;

CAS number : 205923-56-4;

Drug name : Erbitux;

Molecule name : IMC-C225; C 225; C-225;

NSC code : 714692;

Codes from synonyms : CDR0000505985; 50540; CDR0000045467; 98;

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25/05/2025


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