NCIt definition : A recombinant, chimeric monoclonal antibody directed against the epidermal growth
factor (EGFR) with antineoplastic activity. Cetuximab binds to the extracellular domain
of the EGFR, thereby preventing the activation and subsequent dimerization of the
receptor; the decrease in receptor activation and dimerization may result in an inhibition
in signal transduction and anti-proliferative effects. This agent may inhibit EGFR-dependent
primary tumor growth and metastasis. EGFR is overexpressed on the cell surfaces of
various solid tumors.;
Alternative definition : NCI-GLOSS: A monoclonal antibody used to treat certain types of head and neck cancer,
and colorectal cancer that has spread to other parts of the body. It is also being
studied in the treatment of other types of cancer. Monoclonal antibodies are made
in the laboratory and can locate and bind to cancer cells. Erbitux binds to the epidermal
growth factor receptor (EGFR), which is found on the surface of some types of cancer
cells.;
UNII : PQX0D8J21J;
CAS number : 205923-56-4;
Drug name : Erbitux;
Molecule name : IMC-C225; C 225; C-225;
NSC code : 714692;
Codes from synonyms : CDR0000505985; 50540; CDR0000045467; 98;