" /> Anti-OX40 Agonist Monoclonal Antibody GEN1055 - CISMeF





Preferred Label : Anti-OX40 Agonist Monoclonal Antibody GEN1055;

NCIt synonyms : Agonistic Anti-OX40 Monoclonal Antibody GEN1055;

NCIt definition : An agonistic, hexabody-based monoclonal antibody that recognizes the co-stimulatory receptor OX40 (CD134; tumor necrosis factor receptor superfamily member 4; TNFRSF4), with potential immunostimulatory and antineoplastic activities. Upon administration, anti-OX40 agonist monoclonal antibody GEN1055 selectively targets and binds to OX40, thereby forming a hexamer and inducing OX40 clustering. This activates OX40 and induces the proliferation of memory and effector T-lymphocytes and inhibits the function of T-regulatory cells (Tregs) in the tumor microenvironment (TME). This enhances anti-tumor immune responses and prevents Tregs-mediated immune suppression. OX40, a cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes and plays an essential role in T-cell activation and differentiation.;

Molecule name : GEN-1055; GEN 1055; BNT 315; BNT-315;

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31/07/2025


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