Apolizumab - CISMeF

Preferred Label : Apolizumab;

NCIt synonyms : Monoclonal antibody 1D10; Monoclonal Antibody Hu1D10; MoAb Hu1D10; 1D10 Anti-lymphoma Antibody; MAbHu1D10;

NCIt related terms : MoAb: Hu1D10;

NCIt definition : A humanized monoclonal antibody directed against 1D10, a polymorphic determinant on the HLA-DR beta chain that is expressed on normal and neoplastic B cells. Apolizumab induces complement-mediated cytotoxicity, antibody-dependent cell-mediated cytotoxicity, and apoptosis of 1D10 antigen-positive B cells in vitro. (NCI04);

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of hematologic (blood) cancers. Apolizumab binds to a protein called ID10, which is found on the surface of some types of immune cells and cancer cells. It may help the immune system kill cancer cells. It is a type of monoclonal antibody.;

UNII : G88KCP51RE;

CAS number : 267227-08-7;

Drug name : Remitogen;

NSC code : 704867; 710066;

Codes from synonyms : CDR0000045051; NSC0710066;

Details

Origin ID

C2228;

UMLS CUI

C1122758;

Currated CISMeF NLP mapping
- apolizumab [MeSH concept]
- apolizumab [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- apolizumab [MeSH Supplementary Concept]
- apolizumab [MeSH concept]
chemical_or_drug_affects_cell_type_or_tissue
- B-Lymphocyte [NCIt concept]
chemical_or_drug_affects_gene_product
- HLA-DR Antigen [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Antibody-Dependent Cellular Cytotoxicity [NCIt concept]
- Complement-Dependent Cytotoxicity [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- HLA Class II Histocompatibility Antigen DRB [NCIt concept]
is_component_of_chemotherapy_regimen
- Apolizumab/Rituximab [NCIt concept]
- Filgrastim/Monoclonal Antibody Hu1D10 [NCIt concept]

Keyword's position in hierarchy(ies) :

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