HLA-DR Antigen

Preferred Label : HLA-DR Antigen;

NCIt synonyms : Human Leukocyte Antigen - DR Isotype; Human Leukocyte Antigen-DR Isotype;

NCIt related terms : HLA-DR;

NCIt definition : Encoded by multiple HLA-DRA and HLA-DRB genes in a complex variable 5 cM region of MHC between HLA-B and -D, HLA-DR Antigens are Class II histocompatibility transmembrane glycoprotein heterodimers of alpha (heavy, 35-kD) and beta (light, 27-kD) chains. Located predominantly on B cells and macrophages, HLA-DR antigens function in antigen presentation to regulatory T cells in the immune response and in self/nonself discrimination. Invariant alpha and polymorphic beta chains have glycosylated N-termini, hydrophobic membrane regions, and hydrophilic C-termini. The heterodimer consists of 4 extracellular domains; invariant alpha-1, polymorphic N-terminal beta-1, and conserved Ig-like alpha-2 and beta-2. Alpha-1 and alpha-2 contain disulfide loops. Beta-1 contains 2 small variable regions. Alpha sequences have relatively simple structure; beta chains carry the major polymorphic determinants.;

Details

Origin ID

C16692;

UMLS CUI

C0019764;

Automatic exact mappings (from CISMeF team)
- HLA-D antigens [MeSH concept]
- HLA-D antigens [MeSH Descriptor]
- HLA-DQ [LOINC component]
- HLA-DQ antigens [MeSH Descriptor]
- HLA-DR+ cells [LOINC component]
- Human leukocyte antigen D (substance) [SNOMED CT concept]
- hla-d antigen, nos [SNOMED Notion]
Currated CISMeF NLP mapping
- HLA-DR [LOINC component]
- HLA-DR Ag [LOINC component]
- HLA-DR antigens [MeSH Descriptor]
- HLA-DR antigens [MeSH concept]
- Human leukocyte antigen DR (substance) [SNOMED CT concept]
- hla-dr antigen, nos [SNOMED Notion]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- HLA-DR [LOINC component]
- HLA-DR Ag [LOINC component]
- HLA-DR antigens [MeSH concept]
- HLA-DR antigens [MeSH Descriptor]
- Human leukocyte antigen DR (substance) [SNOMED CT concept]
- hla-dr antigen, nos [SNOMED Notion]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
gene_encodes_gene_product
- Immunoprotein Gene [NCIt concept]
- MHC Class II Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Apolizumab [NCIt concept]
gene_product_expressed_in_tissue
- CD4-Positive T-Lymphocyte [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
- HLA Complex [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Antigen Presentation [NCIt concept]
- Immune Response Process [NCIt concept]
- Immune System Process [NCIt concept]
- Immunoregulation [NCIt concept]
is_target
- Anti-HLA-DR Monoclonal Antibody IMMU-114 [NCIt concept]

Keyword's position in hierarchy(ies) :

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